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Zebrafish’s Regeneration Secrets Could Transform Human Therapy

United States: A fish might be the answer to the treatment of human spinal cord injury, as stated by researchers.
Zebrafish’s Unique Healing Mechanism
In zebrafish, the damaged nerve cells are capable of life subsequent to the spinal cord injury to enable complete motor functions in the fish, as reported by HealthDay.
That’s very unhuman, and unlike most other mammals where impaired neurons are doomed to death, researchers noted.
However, the new study reveals that the neuronal survival and subsequent regeneration in the zebrafish model contradict certain paradigms that the research attempts to employ in order to treat human spinal cord injuries.
Neurons in the zebrafish spinal cord are severely affected as they shift their function, particularly the ability to survive. They then assume other roles, of leading to the specific activities that promote healing.
Neuronal Survival and Plasticity
“In zebrafish, we think severed neurons can overcome the stress of injury because their flexibility helps them establish new local connections immediately after injury,” said senior researcher Mayssa Mokalled, an associate professor of developmental biology with the Washington University School of Medicine in St. Louis.

“Our research suggests this is a temporary mechanism that buys time, protecting neurons from death and allowing the system to preserve neuronal circuitry while building and regenerating the main spinal cord,” Mokalled added in a university news release.
This is quite different from how human neurons react to any form of injury. When the spinal cord is compressed or injured, it unleashes toxic signals that lead to the death of the neurons and suppress the healing, stated the researchers.
Challenges in Human Treatments
This toxic response could explain why attempts to recover spinal cord injuries through experimental stem cell therapy have not yielded positive results, scientists have noted.
Contrary to other strategies that have explored the relocation of stem cells to generate neurons, any therapy that aims at restoring the damaged spinal cord in man must first seek to preserve the jeopardy neurons from death, scientists suggested.
“We found that most, if not all, aspects of neural repair that we’re trying to achieve in people occur naturally in zebrafish,” Mokalled said.
“The surprising observation we made is that there are strong neuronal protection and repair mechanisms happening right after injury,” Mokalled noted. “We think these protective mechanisms allow neurons to survive the injury and then adopt a kind of spontaneous plasticity — or flexibility in their functions — that gives the fish time to regenerate new neurons to achieve full recovery.”
Potential for New Therapies
Scientists’ report indicates that such nerve cell healing exists but is inactive in mammals to some extent, which might open a new way toward therapies that would work and cure spinal cord injuries, as reported by HealthDay.
“Our study has identified genetic targets that will help us promote this type of plasticity in the cells of people and other mammals,” Mokalled said. “We are hopeful that identifying the genes that orchestrate this protective process in zebrafish — versions of which also are present in the human genome — will help us find ways to protect neurons in people from the waves of cell death that we see following spinal cord injuries.”
The researchers are to continue the study by investigating how other cell types can help in spinal cord regeneration and comparing the findings with those obtained from mammal cells.
News
UN Warns: Bird Flu Could Devastate Global Economy

United States: A United Nations food agency has issued a stark warning about the rapid spread of the H5N1 bird flu virus, calling it an “unprecedented” global food safety threat that requires urgent, coordinated action.
Escalating Crisis: Millions of Birds Lost
A Food and Agriculture Organization (FAO) United Nations briefing identified worldwide poultry death masses and rising infections that cross between animal groups. Wild bird populations suffered from H5N1 disease in more than 300 species starting in 2021 and causing its spread to new distances according to The Hills.
FAO Deputy Director-General Godfrey Magwenzi emphasized the severe consequences:
“The disease is leading to serious impacts on food security, rural jobs, and rising consumer costs.”
Call for Coordinated Global Action
Beth Bechdol shared his opinion as another FAO Deputy Director-General that nations must collaborate to achieve desired outcomes.

According to an old wisdom a chain achieves its maximum strength through its least robust element. Animal health protection alongside human health protection can be achieved through international collaboration to decrease the impact of bird flu in both local and international scales.
The FAO recommends nations to enhance their bird flu surveillance capabilities while bettering their reporting systems and increasing laboratory capacities and implementing vaccination strategies together with biosecurity measures.
Bird Flu in the U.S.: Impact and Response
According to the CDC, the U.S. is currently managing 70 bird flu cases, affecting 41 dairy farms and 24 egg-producing facilities. While officials state there is no evidence of human-to-human transmission, concerns remain over its impact on the food supply.
The U.S. Department of Agriculture started a $1 billion plan which aims to battle the virus along with stabilizing egg market prices. The existing economic consequences of the virus outbreak have commenced.
#UN agency warns of ‘unprecedented’ #bird #flu threat as #H5N1 #virus jumps to #mammals …
— Microbes.info (@MicrobesInfo) March 19, 2025
| #pathogen | #infections | #AvianInfluenza | #birdflu | #avianflu | #publichealth | By @thisisbartosz.bsky.social via @politico.eu https://t.co/whr6b8ZX6I
Egg Prices Surge as Outbreak Disrupts Supply
The outbreak has created higher egg prices which forces restaurants to make customers pay more for meals with eggs. News reports indicate that the Justice Department began investigating important egg producers after discovering evidence of price manipulation related to the bird flu crisis.
New Bird Flu Strain Discovered in Mississippi
A bird flu strain of heightened virulence that the U.S. had not seen since 2017 was identified in a Mississippi commercial bird herd. Officials confirmed the new strain does not originate from the current H5N1 epidemic but experts remain watchful due to The Hills report.
What’s Next?
Global health experts advise taking rapid coordinated actions to stop the bird flu outbreak from escalating further because of growing worries regarding food safety and monetary consequences. Surveillance strengthening combined with preventive investments and market price fairness stands as the vital foundation for controlling the ongoing crisis.
News
Daytime Sleepiness in Seniors Linked to Higher Dementia Risk

United States: Drowsy during the daytime?
Research findings suggest that daytime sleepiness among senior citizens signals an elevated risk of dementia development.
The journal Neurology published research showing women aged 80 experienced two times greater risk of dementia when their daytime sleepiness increased throughout five years, as reported by HealthDay.
Sleep Disruptions May Be an Early Warning Sign
“The brain requires sleep for cognitive health because this rest period allows mental rejuvenation to improve clear thinking and information retention” according to senior researcher Yue Leng who serves as associate professor of psychiatry at the University of California-San Francisco in the news release.
According to Leng sleep-related problems seem to affect cognitive aging processes and might detect or increase risks for dementia in women aged 80 years old.
Study Tracks Sleep Patterns and Cognitive Decline
The research team studied 733 women who were 83 years old on average for five years. The participants showed no signs of dementia or mild cognitive impairment when the study began.

Women utilized wrist devices during the three-day tracking phase at the study commencement point, followed by the termination point.
The devices monitored sleep pattern variations among 56% of participants across five years.
During the five-year study period, 22% of participants developed mild cognitive impairment, alongside 13% who suffered from dementia.
Sleep pattern shifts are linked to potential brain deterioration, according to results obtained in the study.
Among the study participants who maintained consistent sleep patterns, dementia developed in 8% but increased to 15% among those whose nighttime sleep deteriorated and reached 19% among participants who experienced daytime sleepiness.
Dementia Risk More Than Doubles with Daytime Sleepiness
Research outcomes showed that women experiencing increased sleepiness demonstrated a dementia risk, which was 2.2 times higher after accounting for additional risk variables.

“We observed that sleeping, napping, and circadian rhythms can change dramatically over only five years for women in their 80s,” Leng said.
“This highlights the need for future studies to look at all aspects of daily sleep patterns to better understand how changes in these patterns over time can be linked to dementia risk,” she added.
Experts Call for Sleep-Focused Interventions
The study findings suggest sleep serves as an essential brain protectant, according to Dr. Marino Muxfeldt Bianchin and his editorial partner, who are professors of internal medicine at the Federal University of Rio Grande do Sul in Brazil, as reported by HealthDay.
“Initiatives focusing on improving sleep efficiency, encouraging lifestyle changes, and implementing cognitive interventions may be essential in mitigating dementia risk in the aging population,” Bianchin wrote.
News
CDC Warns of Rising Dengue Fever Cases Among U.S. Travelers

United States: The Centers for Disease Control and Prevention has issued a warning about increasing dengue fever cases among U.S. travelers who are projected to experience more cases throughout this year.
Record-High Cases Reported, Surge Expected in 2025
The number of dengue fever cases detected among U.S. travelers reached “record high” levels during the previous year when 3,484 cases were reported which marked an 84 percent surge from the previous figures, as reported by The Hills.
“This trend is expected to continue with increased dengue activity in endemic areas in 2025,” the warning from the CDC reads.
High Transmission in the U.S. Territories
Dengue transmission continues at high levels across specific United States regions together with selected global areas, while Puerto Rico, along with the U.S. Virgin Islands, attains similar transmission rates within the Americas.

Travelers can acquire dengue with greater ease when they visit sunnier regions from March through September, which heightens their risk of infection.
Recent years have brought a growing number of virus cases and these increases primarily affect the Americas based on World Health Organization (WHO) reports.
Developing nations reported 7.6 million virus cases to the WHO in 2024, showing 3.4 million confirmed cases along with over 16,000 serious cases and more than 3,000 fatalities from the disease.
Dengue fever cases in Puerto Rico have continued to surpass the outbreak threshold since Last February 2024. Public health declared an emergency status in March 2024 and continues to this day.

Dengue cases on the island totaled 6,291 for 2024 alongside more than 52 percent of patients needing hospital care and 13 fatalities documented by the CDC.
U.S. Hotspots for Travel-Related Cases
Recommendations have been issued for a dengue outbreak emergency in the U.S. Virgin Islands since August 2024 and remain current, as reported by The Hills.
A total of 208 dengue cases occurred in 2024, followed by 30 cases in 2025, according to early March records. The Centers for Disease Control and Prevention recorded that Florida, California and New York had the most travel-associated dengue cases throughout 2024.
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