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Asthma Drug Linked to Psychiatric Side Effects 

Asthma Drug Linked to Psychiatric Side Effects. Credit | Reuters

United States: Research by U.S. government researchers revealed that venlafaxine, an asthma drug marketed by Merck and Co, might cause some level of mental deterioration in some patients, a scientific presentation that was seen by Reuters revealed. 

A History of Warnings and Investigations 

The researchers said that the drug marketed as Singulair and generically known as montelukast binds to several important receptors in the brain related to psychiatric disorders, as reported by Reuters. 

Singulair was one of Merck’s largest-selling products after it was launched in the market in 1998. It was marketed as relief in a pill rather than in an inhaler. Initially, the company claimed the therapy had trivial side effects and compared them to taking a placebo or a sugar pill, but ‘any distribution of the substance in the brain was minimal.’ Nevertheless, generics continue to be dispensed to millions of adults and children annually. 

But by 2019, thousands of reports of neuropsychiatric episodes, including dozens of suicides in patients taking the drug, appeared on the forums and in the U.S. FDA database. Such “adverse event” reports do not establish the connection between a medicine and a side effect and aren’t used to designate legal responsibility. Instead, they are used by the FDA to decide whether further investigation of a drug’s risks is needed. 

Over the years, stacking up numerous reports and new research, the scientific agency of the United States, the  FDA, in the year 2020 included the so-called “black box” warning on the prescribing information of montelukast highlighting the potential risks of serious mental health side effects including suicidal thoughts or actions. 

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Around the same time, the agency assembled a team of internal consultants to investigate why the drug may lead to neuropsychiatric side effects

The findings of the group, which have not been published before, are still in their raw form and were shared only with a select audience at the American College of Toxicology meeting in Austin, Texas, on Wednesday. 

At the event, Oliphant from the FDA’s National Centre for Toxicological Research went on to say that laboratory tests indicated that montelukast is bound to numerous receptors discovered in the brain. 

Scientific Findings Raise More Questions 

The FDA also validated the research conducted previously that proved montelukast crossed the blood-brain barrier of rats. Further research is required on how the drug gets concentrated in the nervous system, the author opined Oliphant. “These data suggest that montelukast is most accumulated in brain areas thought to be related to (psychiatric effects),” she added. 

The FDA said that it has no intention of revising the drug label according to the information demonstrated at the presentation. 

‘SOMETHING THAT’S CONCERNING’ 

Based on FDA slides seen by Reuters, montelukast behaves like other drugs that were cited for having neuropsychiatric-like effects, such as risperidone, which is an antipsychotic drug. The FDA has sounded a word of caution regarding their studies, noting that they are still in progress and, therefore, the outcome has not been concluded. 

When the FDA added the black box, it based it on research from Julia Marschallinger and Ludwig Aigner of Austria’s Institute of Molecular Regenerative Medicine. 

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The two scientists said during an interview with Reuters on Thursday that the new data depicted that montelukast is the latest in the brain. The receptors involved have a function of controlling mood, impulse control, cognition, and sleep, among others, they said. 

The study also does not indicate whether that binding mechanism causes negative consequences in patient outcomes or which patients might be most susceptible, as the two researchers marked. However, Marschallinger said the new data strengthens the testimony of the people who claimed to have side effects. 

“It’s definitely doing something that’s concerning,” she said. 

Questions were not answered by a Merck representative. Organon, a Merck subsidiary now selling Singulair, expressed confidence in the medication’s safety profile in a statement. 

“The product label for Singulair contains appropriate information regarding Singulair benefits, risks, and reported adverse reactions,” the company said. 

Reported Side Effects and Legal Challenges 

Reuters said last year that it has thousands of FDA reports of patients, including children, who developed depression, suicidal thoughts and behaviors, or other psychiatric side effects after using montelukast. 

Now, that list has grown to 82 suicides attributed to Singulair and its generic counterparts as reported to the FDA’s adverse-event database since 1998. In at least 31 of those reports, an individual was under the age of 19 years of age. 

Reported Side Effects and Legal Challenges 

Nick, the 22-year-old son of Robert England, committed suicide in 2017 after he began taking Montelukast, with it being less than two weeks. England remembers that his son had a sleep disorder four days before his death and assured him he was not mentally ill when he consumed the drug, as reported by Reuters. 

“He was on that medication for just days, literally just days,” England said. “It completely changed the trajectory of our lives.” 

The Reuters report also described litigation contending that Merck learned during the development of the drug that it affected the brain and downplayed the risk of psychiatric side effects to authorities. Some of those lawsuits are still awaiting trial. 

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UN Warns: Bird Flu Could Devastate Global Economy 

UN Warns: Bird Flu Could Devastate Global Economy 

United States: A United Nations food agency has issued a stark warning about the rapid spread of the H5N1 bird flu virus, calling it an “unprecedented” global food safety threat that requires urgent, coordinated action. 

Escalating Crisis: Millions of Birds Lost 

A Food and Agriculture Organization (FAO) United Nations briefing identified worldwide poultry death masses and rising infections that cross between animal groups. Wild bird populations suffered from H5N1 disease in more than 300 species starting in 2021 and causing its spread to new distances according to The Hills. 

FAO Deputy Director-General Godfrey Magwenzi emphasized the severe consequences: 

“The disease is leading to serious impacts on food security, rural jobs, and rising consumer costs.” 

Call for Coordinated Global Action 

Beth Bechdol shared his opinion as another FAO Deputy Director-General that nations must collaborate to achieve desired outcomes. 

UN Warns: Bird Flu Could Devastate Global Economy 
UN Warns: Bird Flu Could Devastate Global Economy 

According to an old wisdom a chain achieves its maximum strength through its least robust element. Animal health protection alongside human health protection can be achieved through international collaboration to decrease the impact of bird flu in both local and international scales. 

The FAO recommends nations to enhance their bird flu surveillance capabilities while bettering their reporting systems and increasing laboratory capacities and implementing vaccination strategies together with biosecurity measures. 

Bird Flu in the U.S.: Impact and Response 

According to the CDC, the U.S. is currently managing 70 bird flu cases, affecting 41 dairy farms and 24 egg-producing facilities. While officials state there is no evidence of human-to-human transmission, concerns remain over its impact on the food supply. 

The U.S. Department of Agriculture started a $1 billion plan which aims to battle the virus along with stabilizing egg market prices. The existing economic consequences of the virus outbreak have commenced. 

Egg Prices Surge as Outbreak Disrupts Supply 

The outbreak has created higher egg prices which forces restaurants to make customers pay more for meals with eggs. News reports indicate that the Justice Department began investigating important egg producers after discovering evidence of price manipulation related to the bird flu crisis. 

New Bird Flu Strain Discovered in Mississippi 

A bird flu strain of heightened virulence that the U.S. had not seen since 2017 was identified in a Mississippi commercial bird herd. Officials confirmed the new strain does not originate from the current H5N1 epidemic but experts remain watchful due to The Hills report. 

What’s Next? 

Global health experts advise taking rapid coordinated actions to stop the bird flu outbreak from escalating further because of growing worries regarding food safety and monetary consequences. Surveillance strengthening combined with preventive investments and market price fairness stands as the vital foundation for controlling the ongoing crisis. 

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Daytime Sleepiness in Seniors Linked to Higher Dementia Risk 

Daytime Sleepiness in Seniors Linked to Higher Dementia Risk 

United States: Drowsy during the daytime? 

Research findings suggest that daytime sleepiness among senior citizens signals an elevated risk of dementia development. 

The journal Neurology published research showing women aged 80 experienced two times greater risk of dementia when their daytime sleepiness increased throughout five years, as reported by HealthDay. 

Sleep Disruptions May Be an Early Warning Sign 

“The brain requires sleep for cognitive health because this rest period allows mental rejuvenation to improve clear thinking and information retention” according to senior researcher Yue Leng who serves as associate professor of psychiatry at the University of California-San Francisco in the news release. 

According to Leng sleep-related problems seem to affect cognitive aging processes and might detect or increase risks for dementia in women aged 80 years old. 

Study Tracks Sleep Patterns and Cognitive Decline 

The research team studied 733 women who were 83 years old on average for five years. The participants showed no signs of dementia or mild cognitive impairment when the study began. 

Daytime Sleepiness in Seniors Linked to Higher Dementia Risk 
Daytime Sleepiness in Seniors Linked to Higher Dementia Risk 

Women utilized wrist devices during the three-day tracking phase at the study commencement point, followed by the termination point. 

The devices monitored sleep pattern variations among 56% of participants across five years. 

During the five-year study period, 22% of participants developed mild cognitive impairment, alongside 13% who suffered from dementia. 

Sleep pattern shifts are linked to potential brain deterioration, according to results obtained in the study. 

Among the study participants who maintained consistent sleep patterns, dementia developed in 8% but increased to 15% among those whose nighttime sleep deteriorated and reached 19% among participants who experienced daytime sleepiness. 

Dementia Risk More Than Doubles with Daytime Sleepiness 

Research outcomes showed that women experiencing increased sleepiness demonstrated a dementia risk, which was 2.2 times higher after accounting for additional risk variables. 

Daytime Sleepiness in Seniors Linked to Higher Dementia Risk 
Daytime Sleepiness in Seniors Linked to Higher Dementia Risk 

“We observed that sleeping, napping, and circadian rhythms can change dramatically over only five years for women in their 80s,” Leng said. 

“This highlights the need for future studies to look at all aspects of daily sleep patterns to better understand how changes in these patterns over time can be linked to dementia risk,” she added. 

Experts Call for Sleep-Focused Interventions 

The study findings suggest sleep serves as an essential brain protectant, according to Dr. Marino Muxfeldt Bianchin and his editorial partner, who are professors of internal medicine at the Federal University of Rio Grande do Sul in Brazil, as reported by HealthDay. 

“Initiatives focusing on improving sleep efficiency, encouraging lifestyle changes, and implementing cognitive interventions may be essential in mitigating dementia risk in the aging population,” Bianchin wrote. 

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CDC Warns of Rising Dengue Fever Cases Among U.S. Travelers 

CDC Warns of Rising Dengue Fever Cases Among U.S. Travelers. credit | AP

United States: The Centers for Disease Control and Prevention has issued a warning about increasing dengue fever cases among U.S. travelers who are projected to experience more cases throughout this year.   

Record-High Cases Reported, Surge Expected in 2025 

The number of dengue fever cases detected among U.S. travelers reached “record high” levels during the previous year when 3,484 cases were reported which marked an 84 percent surge from the previous figures, as reported by The Hills. 

“This trend is expected to continue with increased dengue activity in endemic areas in 2025,” the warning from the CDC reads.   

High Transmission in the U.S. Territories 

Dengue transmission continues at high levels across specific United States regions together with selected global areas, while Puerto Rico, along with the U.S. Virgin Islands, attains similar transmission rates within the Americas.   

CDC Warns of Rising Dengue Fever Cases Among U.S. Travelers 
CDC Warns of Rising Dengue Fever Cases Among U.S. Travelers 

Travelers can acquire dengue with greater ease when they visit sunnier regions from March through September, which heightens their risk of infection.   

Recent years have brought a growing number of virus cases and these increases primarily affect the Americas based on World Health Organization (WHO) reports.   

Developing nations reported 7.6 million virus cases to the WHO in 2024, showing 3.4 million confirmed cases along with over 16,000 serious cases and more than 3,000 fatalities from the disease.   

Dengue fever cases in Puerto Rico have continued to surpass the outbreak threshold since Last February 2024. Public health declared an emergency status in March 2024 and continues to this day. 

CDC Warns of Rising Dengue Fever Cases Among U.S. Travelers 
CDC Warns of Rising Dengue Fever Cases Among U.S. Travelers 

Dengue cases on the island totaled 6,291 for 2024 alongside more than 52 percent of patients needing hospital care and 13 fatalities documented by the CDC.   

U.S. Hotspots for Travel-Related Cases 

Recommendations have been issued for a dengue outbreak emergency in the U.S. Virgin Islands since August 2024 and remain current, as reported by The Hills. 

A total of 208 dengue cases occurred in 2024, followed by 30 cases in 2025, according to early March records. The Centers for Disease Control and Prevention recorded that Florida, California and New York had the most travel-associated dengue cases throughout 2024. 

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